Top 50 Most Popular Female Anime Villains Of All Time

top 50 most popular female anime villains of all time

 

Villains. Without a doubt, one of the most crucial aspects of any story. And stories featured in anime are no exception to it.

 

This is why we have some of the most fascinating villains to ever exist in the entertainment media. However, just like every other category, this one is also filled with a ton of males as candidates.

 

But that doesn’t mean that there are no female anime villains. There are a ton of them. It’s just that they don’t receive enough recognition from fans.

 

And this is the exact reason why I have decided to list down the Most Popular Female Anime Villains.

 

If you are in search of an evil Waifu, this is the list for you. I hope you enjoy it!

 

 

 

1. Echidna (Re:Zero)

 

echidna (re:zero)

 

This white-haired lady is the one from Re: Zero who shaped the show in her own way.

 

She is a witch who keeps a keen eye on Subaru and has close relations with him. The narrative of Rezero is a bit more complex than you might expect.

 

And so, it isn’t easy to explain why she appears as often as she does. However, the fact stands true.

 

She is a unique character who is a villain but doesn’t feel like one. She is the reason why our characters suffer so much.

 

However, she is not the one having fun because of their suffering. And since this creates such an interesting situation for us viewers as a female anime villain, she deserves to be on our list.

 

 

 

2. Krul Tepes (Seraph Of The End)

 

Krul Tepes

 

Krul Tepes is one of the most demanding characters in the entire series. No questions about it. However, that’s just the beginning of her personality.

 

She is from the popular anime series we call Seraph Of The End. And as someone who serves as a villain, she does her job very well.

 

She is the one who changed our main cast and their relationships without even knowing about it. And as the show progresses, she goes on to shape herself as an even crueler villain for the story.

 

She does some of the most hideous things for the show and goes on to prove herself as one of the most notable characters in the franchise. This is why she is ranked so high.

 

 

 

3. Daki (Demon Slayer)

 

daki (demon slayer)

 

Daki’s rocking the Upper Moon demon status in the show, sharing the Upper Moon Rank 6 spotlight with her brother Gyutaro. Talk about a dynamic duo!

 

This demon diva isn’t just strong; she’s got an attitude to match.

 

In the entertainment district, where beauty is queen, Daki’s the belle of the ball. Being the most beautiful woman in town doesn’t just come with looks; it comes with respect too.

 

Our heroes, led by Tanjiro, had a tough time dealing with this fierce demon. But guess who swooped in for the win? Uzui, takes care of business like a boss.

 

All in all, Daki’s proving to be a top-tier female villain in an already fantastic show. Beauty, strength, and a dash of arrogance – she’s the total package!

 

 

 

4. Raynare (High School DxD)

 

Raynare

 

She is a horrible girl who deserves more hate and disrespect from the fandom. And that’s the exact reason why she is so impressive as a villain.

 

Raynare is one of the lead characters in High School DxD. And she was the one who shaped the show the way it is today.

 

She asked out Issei on a date only to end up killing him. However, that’s not the reason why people hate her so much.

 

It is because she played with Issei’s genuine feelings that she is disrespected so much. Just look at her behavior towards Issei as he was taking his last breaths.

 

Now that’s a disgusting incident. And that’s why Raynare is ranked so high on our list.

 

 

5. Jessie (Pokemon)

 

Jessie

 

Jessie is a name that everyone reading this list might remember. And that’s because you would hear it all the time while watching your favorite childhood anime named Pokemon.

 

She is part of Team Rocket which is an evil organization in search of some of the strongest Pokemon for their mean purposes.

 

Jessie is the one who is the unsaid leader of the group and makes the decision on behalf of everyone else.

 

She goes on to prove herself as a strong woman who can take care of her opponents when the situation calls for it.

 

However, since the Pokemon anime is made for kids, she fails to proclaim her excellence as the show uses plot Armor.

 

 

6. Android 18 (Dragon Ball Z)

 

Android 18

 

She is one of the older female anime villains. And this is why she deserves so much love and respect from fans all around the globe.

 

Android 18 is one of the lead female characters in Dragon Ball Z who happens to be a villain in the start but now serves as one of the heroes.

 

She is the one who was designed with the task of creating the Perfect Cell. And with her powers combined, Cell became a monster so strong that none was able to beat him.

 

Android 18 became a lot more tranquil after the completion of the Cell saga. And she married Krillin which made her a part of the Z fighters group. This is why she is placed here.

 

 

7. Isabella (The Promised Neverland)

 

Isabella

 

She is the one who made The Promised Neverland, an incredible watch for all of us. Isabella is the lead female in the series and has a lot going on for her.

 

She is one of the adults in the show who have been assigned the task of raising the children to be eaten by the Monsters.

 

Yeah, that’s exactly how it goes. And that’s just the beginning of it. She is also extremely clever and strong as portrayed in the series.

 

And as a human, she developed a sense of motherly love as the show progresses. Soon enough, we realize that this girl is a beast on her own and can manipulate the show without breaking a sweat.

 

And that’s why she became a remarkable villain for all of us.

 

 

8. Annie Leonhart (Attack On Titan)

 

Annie Leonhart

 

Annie Leonhart is one of the most notable characters in Attack On Titan. And while we don’t see much from her after the first season, she did pack a punch during her arc.

 

She is the female Titan in the show who has a lot of information about the upbringing of Titans and their activities.

 

However, when the time of revelation came to be, she managed to keep her secrets as secrets and froze herself into a shell.

 

Her fight with Eren was a game-changing battle that shaped the series in the long run and allowed the audience to have a thorough perspective of Eren and his personality.

 

Annie may not speak much but she did impact the show from the depths of her heart.

 

 

9. Himiko Toga (My Hero Academia)

 

Himiko Toga

 

She might not be the next boss villain of her anime, but she does manage to leave an impact.

 

Himiko Toga is one of the main characters in My Hero Academia. And she is a part of the League Of Villains.

 

Her Quirk allows her to change her body composition similar to the one she has the blood from. And that’s the exact reason why she is so lethal in combat.

 

She might have disguised herself as your ally, only to end up backstabbing you from the inside. And that’s why Himiko is such a menace to the series.

 

She is an impressive female character who deserves more love and recognition from the anime fandom as a whole.

 

 

10. Rize Kamishiro (Tokyo Ghoul)

 

Rize Kamishiro

 

It is because of her that Tokyo Ghoul became what it is today. And that’s what makes Rize so special.

 

She is one of the lead characters in her show and happens to be one of the evilest people in the show.

 

She took over Kaneki during her accident. And while she wasn’t able to take 100% control over her body, Rize did manage to get a lot of attention within her mind of Kaneki.

 

There’s a reason why people loved her even though she was a villain. She highlighted the darkness present in the Ghoul realm and influenced Ken to become the monster that he is today.

 

And this is the reason why Rize is one of the most impressive characters in the entire show.

 

 

11. Makima (Chainsaw Man)

 

makima (chainsaw man)

 

Let’s dive into the world of Chainsaw Man and meet Makima, the queen bee of complexity and ruthlessness!

 

Makima is no ordinary character – she’s the brains, beauty, and boss lady of the Public Safety Devil Hunters, leading the charge in Special Division 4. Picture this: always smiling, cool as a cucumber, even in the craziest situations. But don’t be fooled by the calm exterior; beneath it, she’s a mastermind, plotting her way up the career ladder.

 

This lady isn’t just feared by humans; even Fiends and Devils worldwide quake in her presence. Why? Because she’s got big plans, aiming to use Chainsaw Man to reshape the world for the better.

 

 

12. Lust (Fullmetal Alchemist Brotherhood)

 

Lust

 

She is one of the most attractive female villains. However, her actions make her even more attractive as a villain.

 

Lust is one of the seven deadly sins highlighted in the Fullmetal Alchemist Brotherhood anime series. However, what makes lust so special is the fact that she can cause a ton of havoc without breaking a sweat.

 

There’s a reason why people look up to her and have a positive image of her. She was taken down by Roy Mustang and her fight against him was sort of one-sided.

 

However, she proved her skills time and time again in the series. And that’s why she deserves to rank so high on our list.

 

 

13. Esdeath (Akame Ga Kill)

 

Esdeath

 

This woman is one of the most notable female villains in all of anime. And that’s what makes her so amazing in the first place.

 

Esdeath is one of the lead female characters in the show who happens to be the antagonist of the anime Akame Ga Kill.

 

She is known to be one of the strongest female characters in her show and has an unreal amount of skill within herself.

 

Her battle with Akame is recognized as one of the most outstanding fights in the entire show. And with such acclaim in place, Esdeath goes on to prove herself as a woman of quality and value.

 

She is a beast when it comes to battle and you wouldn’t wanna go up against her.

 

 

14. Kasane Kujiragi (Durarara)

 

kasane kujiragi (durarara)

 

A notable female from Durarara! Now that’s more like it. She is one of the main characters in the series and acts as the lead villain in the second season of the show.

 

She is the one who happens to have the weapon we call Saika. And that allows her to become an insane monster.

 

However, that’s just the surface of her character. She is known to be quite stable on the outside. She doesn’t take any extreme steps during her work and functions in a calm and calculated manner.

 

There’s a reason why people look up to her as a villain in the show. She is sweet yet lethal.

 

 

15. Balalaika (Black Lagoon)

 

Balalaika

 

Black Lagoon is a female-dominated show. And so, the main villain also happens to be a female. However, just like Revy, she is also a potent being with a lot of skills and abilities up her sleeves.

 

And that’s why she is placed here on our list. She is the boss of Hotel Moscow and happens to be one of the most recognized characters in the show.

 

She happens to be extremely rich and had a high-ranking military power under her support. With all these features in place, Balalaika managed to become a noteworthy villain in the Black Lagoon series.

 

And that’s why she deserves to be standing strong. If you haven’t watched her yet, make sure to do so with pride and confidence.

 

 

16. Malty S. Melromarc (Rising of The Shield Hero)

 

Malty S. Melromarc

 

This girl is an absolute monster. And I don’t have words to express how hideous of a character she is.

 

Everyone hates her. And to a certain degree, she is the Shou Tucker of the current generation. Malty S Melromarc is one of the lead characters in Rising of The Shield Hero.

 

And she was the one who tricked our main character into a predicament that changed his life forever. Fortunately, our boy managed to pave his way through all the misery that he faced in his life.

 

However, that wasn’t enough at all. After all, nothing comes close to the brutality that she enforced on our shield hero.

 

And that’s why she is one of the most hated characters in the entire show.

 

 

17. Lucy (Elfen Lied)

 

Lucy

 

While she was the main character of her show, there was no denying that her destructive powers made her a villain for everyone else.

 

She is one of the notable characters in the show we know by the name of Elfen Lied. And her personality is pretty basic on the outside.

 

Nothing unreal at all. However, when we come to know about her past and her capabilities as a whole, the story goes from left to right.

 

Lucy was a science experimenter who managed to escape her facility. However, from that point on she goes on to take care of anything and everything that can cause harm to those around her.

 

However, she doesn’t realize that she is the biggest threat to her known ones. And that’s why she turns out to be a villain in the series.

 

 

18. Junko Enoshima (Danganronpa)

 

Junko Enoshima

 

Coming in from the realm of Danganronpa, we have Junko Enoshima. She is the main villain of the original Danganronpa series and has a lot of interesting features herself.

 

She isn’t a human. And although her physical appearance says otherwise, she is actually an alien who is on her way to capturing humanity.

 

She went ahead and took charge of Hope’s Peak Academy and had the idea to break down the spirit of all those who have been outside Hope as they watch all the characters within the school fall because of their incompetence.

 

However, this is where she goes wrong and ends up creating a motivational situation for everyone else in the series.

 

 

19. Reiko Tamura (Parasyte)

 

Reiko Tamura

 

You may not remember her instantly. However, the memory will surface soon enough. She is the one who served as one of the most notable villains in the series we know by the name of Parasyte.

 

And that’s a feature of its own on the outside. She is a parasite who happens to be a teacher at our main character Izumi’s school.

 

And that’s just the surface of her personality. She is also quite intimidating and captivating as a whole person.

 

And the way she takes on Izumi in the narrative, makes her look even eviler. All in all, Reiko Tamura is a force to be reckoned with.

 

And Parasyte fans know that she made the show a lot more captivating than it was before.

 

 

20. Vermouth (Detective Conan)

 

Vermouth

 

This lady from the realm of the case closed has the potential to take down anyone. And that’s why she deserves this spot on our list.

 

Just in case you don’t remember, Vermouth is one of the notable villains in Detective Conan. And she has a lot going on for her.

 

Firstly, she is associated with the Black Organization and serves as the Executive Member of the same. Moreover, she is also an actress in the story and her name recognition is Sharon Vineyard.

 

There’s a reason why people think she is one of the most attractive characters in the entire series. All in all, Vermouth is a force to be reckoned with as she uses some of the most cunning tactics to stand out in her field of expertise.

 

 

21. Gyokuen Ren (Magi)

 

Gyokuen Ren

 

This girl may not seem like a memorable one from the start. However, she has a lot going on for herself.

 

And that’s why she deserves to be on our list for sure. Gyokuen Ren is one of the lead characters in the Magi series.

 

And if you have watched the Magi series. You would realize that the show has a ton of themes within its narrative.

 

Moreover, she is the one who is standing as a widow for the previous generations. And that’s a huge deal altogether.

 

She is the one who creates some interesting situations in the series that change the course of the show for good.

 

And as someone who is in search of some qualitative anime villain, she stands out very well.

 

 

22. The Witch Queen (Black Clover)

 

The Witch Queen

 

From the realms of Magic, we have Witch Queen. She is one of the notable characters in the show who has a talking frame and a slim body shape going for her.

 

She is known to be the one who caused all the havoc with the witches. And she also serves as the ruler of the Witch Forest.

 

The most interesting feature about her is that she is the mother of all witches which would explain her character as a villain.

 

And her acting as a personality within the narrative is one of the biggest reasons why people take up so much liking towards her.

 

And as a villain, she does her job very well. Plus, we can’t get over the excellence of her design and attire either. This is why she is placed here on our list.

 

 

23. Konan (Naruto)

 

Konan

 

Konan is one of the most outstanding characters in the entire series. And her accomplishments are quite attractive as well.

 

She is the only female member of Akatsuki. And that’s a huge deal considering that Akatsuki only takes in the best of the best as part of their team.

 

Moreover, her powers are focused on paper and the use of these powers is also very creative and captivating.

 

There’s no denying that Konan is one of the most eye-catching characters in the entire series. And with her battles in the show, she managed to gain a ton of respect and appreciation from the Naruto Fandom altogether.

 

 

24. Misa Amane (Death Note)

 

Misa Amane

 

She might not have villainous intentions for the series but her actions have made her be one. Misa Amane is one of the lead females in Death Note and she is known for being the most outstanding one of them all.

 

She was another one of the humans who had a death note in their grasp. And while she used it to get the attention of Yagami Light aka the first Kira, she was able to get her thoughts across as a villain for the show.

 

She didn’t intend any harm to anyone. However, she did kill a lot of criminals in the show. And that’s considered unethical since she is not the justice body, making her a villain for the franchise.

 

 

25. Akito Sohma (Fruits Basket)

 

Akito Sohma

 

She was a villain at the start. However, with the progression of the story, she was able to transform herself into a better person.

 

Akito is the head of the Sohma family and is known to be the one affected by the curse of the God of Zodiacs.

 

She is the one who is known as the daughter of Akira and Ren. And with this affiliation, she happened to get a lot of power in her hands as a character.

 

The series goes on to prove that this character has a broader personality than what meets the eyes. And while we do see her change from start to finish, the transformation was a lot more unexpected and unforeseen than we had initially imagined. This is why it is ranked so high.

 

 

26. Tanya Degurechaff (The Saga Of Tanya The Evil)

 

Tanya Degurechaff

 

Coming in as the main character while also being a villain, we have Tanya Degurechaff. She is the one who takes the idea of The Saga Of Tanya The Evil to the next level.

 

And that’s what makes her so special, to begin with. The story is an Isekai that focuses on a guy who got teleported to a new realm as a young girl.

 

However, he retained the knowledge and wisdom from his previous life. Therefore, he is able to have more discretion for his age than what meets the eye.

 

Essentially, he decides to climb the ladder of the military in this new world. And over time, become the best in this realm.

 

However, when that happens, he will be going against some of the finest in the show.

 

 

27. Kurome (Akame Ga Kill)

 

Kurome

 

Coming from the narrative of Akame Ga Kill, we have Kurome. She is one of the side characters in the show who happens to be a younger sister to the main female Akame.

 

And happens to be part of the Jaegers. It is said that she is second to only General Esdeath which would explain her position as a supporting villain in the storyline.

 

It is claimed that this seemingly harmless girl is able to take on the entirety of Night Raid all on her own.

 

And she was about to claim victory in this approach when things took unexpected turns. This is why Kurome is a character that needs more love and recognition from a viewer’s perspective.

 

This is why she is standing here.

 

 

28. Kiss-shot Acerola-Orion Heart-under-blade (Monogatari)

 

Kiss-shot Acerola-Orion Heart-under-blade

 

She is a menace. And her name is just the surface of how intimidating she can be as a character.

 

Kiss-shot acerola Orion heart under blade or Shinobu is one of the main characters in the Monogatari series. And she is known for having a complex character going on for her.

 

As someone who is a monster from the start, Shinobu doesn’t have a lot of love and appreciation for anyone.

 

However, her relationship with Araragi makes it so that she can express herself more to him. She isn’t exactly a major villain on the outside.

 

But yeah, she did play the role at one point in the series. Therefore, she deserves this spot.

 

 

29. Sailor Galaxia (Sailor Moon)

 

Sailor Galaxia

 

If you are a hardcore anime fan then you might already have an idea as to who this character is.

 

She is one of the leads of Sailor Moon. And oh boy, isn’t she dominating. Sailor Galaxia is one of the lead antagonists of the show who is known for putting a climax to the final arc of Sailor Moon.

 

And that’s just the surface of her excellence. Just look at her design. It is absolutely insane. She happens to have the highest degree of detailing and characterization for her personality.

 

And that says a lot for someone who is into all the minute features that make an anime as incredible as it becomes over time.

 

And this is why Sailor Galaxia deserves to be here on our list.

 

 

30. Priscilla (Claymore)

 

Priscilla (Claymore)

 

Priscilla was destined to become Claymore No. 2 during Teresa’s generation, positioning her as the second most formidable character in the series, surpassing even the Abyssals.

 

As a Claymore, Priscilla displayed exceptional potential as a warrior, capable of fighting without relying on her Yoki.

 

Within a few months, she swiftly ascended to the No. 2 position and was assigned a mission to assassinate Teresa, alongside fellow single-digit Claymores Irene, Noel, and Sophia.

 

However, during this operation, Priscilla reached her breaking point and experienced an Awakening, subsequently becoming the primary antagonist of the story.

 

Priscilla initially appears as a slender girl with short brown hair and brown eyes. Her personality evolves throughout the series, starting with a childlike and emotionally distraught state due to witnessing Yoma kill her family.

 

This traumatic event led her to perceive the world in simplistic terms, branding Teresa as evil for her actions against humans.

 

 

31. Ruri Hijiribe (Durarara)

 

Ruri Hijiribe

 

She might not ring any bells to some of you. However, Durarara fans might have their tingling going on already.

 

Ruri is one of the side characters in the show who happens to have a lot going for her.

 

How? Well, she is an idol and a celebrity who had the misfortune of losing her family as they went bankrupt.

 

And this was the beginning of her downfall. Moreover, she is also known for her appearance as a character.

 

With her red-themed clothes and personality, Ruri goes on to prove herself as a woman of quality and value for the story she is a part of.

 

Therefore, Ruri Hijiribe is a remarkable name for anyone who is into Durarara.

 

 

32. Shalltear Bloodfallen (Overlord)

 

Shalltear Bloodfallen

 

Have you ever watched Overlord? If yes then Shalltear Bloodfallen is a character you need to take into consideration.

 

Shalltear is one of the lead characters in the show who happens to gain a lot of traction thanks to her cute yet creative design.

 

Her attire is pretty detailed and has a theme going on that can melt anyone’s heart. Moreover, she is a sweet-looking girl who might not portray herself as a villain.

 

Unfortunately, she is a major one who can’t be ignored altogether. She is the one who is known for her position as guardian of one of the floors of the Great Tomb.

 

And she is also one of the only True Vampires in the series.

 

 

33. Shiro (Deadman Wonderland)

 

Shiro

 

Coming in as one of the most unique characters in the entire series, we have Shiro. She is one of the main characters from Deadman Wonderland who may seem humble at first.

 

However, the story changes when she goes on to become the monster that is called the Wretched Egg. Once Shiro gets herself into that form, she can become an absolute monster who can cause a ton of havoc while groundbreaking everything and everyone without any problem.

 

There’s a reason why people are intimidated by the name of the Wretched Egg. She is just a lethal creature who can cause a ton of trouble if she wants to.

 

 

34. Shion Sonozaki (Higurashi When They Cry)

 

Shion Sonozaki

 

She is a monster on her own. And there’s a reason why people look up to her as one of the most terrifying characters in her show.

 

Shion Sonozaki is one of the lead characters in the Higurashi When They Cry series. However, that’s just the surface of her character.

 

In the story, she also has a twin sister who is named Mion Sonozaki and she also serves as one of the main characters.

 

However, Shion acts as a villain in the latter half of the show. Shion just goes on to express herself as one of the most dominant and complex characters that the series has to offer. And her green hair just adds more personality to her.

 

 

35. Nana Hiiragi (Talentless Nana)

 

Nana Hiiragi

 

The anime talentless Nana was a big deal back when it first appeared. And that’s what makes this character so notable for all of us.

 

She was one of the lead characters in the series who happens to have a lot going on for her.

 

She is the kind of character who transformed from being a heroine to a villainess or something along those lines.

 

It is hard to express what exactly happened to her character altogether. However, she was definitely a woman of quality and value who transformed into something completely unexpected.

 

And that’s why she is placed here on our list. Make sure to watch Talentless Nana.

 

 

36. Altair (Recreators)

 

Altair

 

This girl is known for her discipline and destruction. And that’s why she is placed so high on our list.

 

Altair is one of the lead villains in Recreators who is known for being the primary antagonist of the show.

 

She is the one who is known as the Military Uniform Princess and this name isn’t as hollow as you might think.

 

It is backed by her skills as a character who is in search of qualities and values within the show.

 

Moreover, she was able to dominate the series with her strict and rough personality. This is why Altair is such a respected character in the anime.

 

She has done a lot to stand where she is. And the main cast has a tough time dealing with her.

 

 

37. Nonon Jakuzure (Kill La Kill)

 

Nonon Jakuzure

 

Coming in from the realm of Kill La Kill, we have Nonon. She is one of the main characters in the show who is known for her eye-catching appearance and charisma.

 

She is one of the 4 students who were part of the school that was scouted by Ryuuko Matoi.

 

And her task was to take care of Ryuuko in a battle. Moreover, she was from the elite four who went against Ryuuko during her search.

 

And her abilities and skills managed to pack a punch in the fight. If we talk about her appearance, she had pink hair and a petite figure going on for herself which makes her look like a unique girl altogether.

 

This is why she deserves this spot on our list.

 

 

38. Ougi Oshino (Monogatari)

 

Ougi Oshino

 

Ougi is a rather unique character. And her personality is even more eye-catching. However, that’s just the beginning of her story.

 

She is one of the lead characters in the Monogatari series. However, she wasn’t part of the series from the start.

 

Instead, she showed up in the later parts of the show and gained the audience’s attention using her completely obscure self-presentation and character sketch that made people question what kind of being she is?

 

She goes on to do some interesting stuff in the story that makes her appear like a villain. And that’s why she is placed here on our list. She is quite a notable girl after all.

 

 

39. Yuno Gasai (Mirai Nikki)

 

Yuno Gasai

 

She is not exactly the villain of the series. However, from someone else’s perspective, she is definitely a bad girl in the show.

 

Yuno Gasai is the lead character of Mirai Nikki who is known for her excellence and presence in the show.

 

She is known to be a Yandere and is often referred to as the best Yandere to ever exist.

 

While there are countless reasons why people refer to her, one of the biggest ones is that Yuno is extremely aggressive.

 

She can cause a lot of trouble to anyone and everyone who is against her love interest. And this is a major issue in the second half of the show, making her worthy of this spot on our list.

 

 

40. Do-S (One Punch Man)

 

Do-S

 

This character was pretty fun to watch when it first appeared. And as a female anime villain, she was quite menacing on her own.

 

Do-S is one of the lead antagonists of One Punch Man who caused a lot of havoc on the streets before being taken care of by one of the main heroes in the show.

 

She wasn’t a major threat. However, the way she went ahead and challenged many of the heroes and asserted her presence in the series made her stand out so much.

 

One-Punch Man has a few more female villains who can entertain the group. However, that’s just the surface of how things will go for this category of female anime villains. And not all of them will be as good as Do-S.

 

 

41. Medusa Gorgon (Soul Eater)

 

Medusa Gorgon

 

The name is good enough to give you an idea as to what kind of role she might be serving.

 

After all, Medusa holds a lot of significance in Japanese stories and narratives. However, this one specifically belongs to the popular anime we know by the name of Soul Eater.

 

She is one of the side characters in the show who serves as a villain in the series. She is a witch who is part of the Gorgon family and happens to be one of the three sisters who are present in the storyline.

 

Moreover, she has a strong connection with Crona, who is one of the notable characters in the series. And she plays the part of Crona’s mother. This is why she is ranked here.

 

 

42. Zazan (Hunter x Hunter)

 

Zazan

 

Coming from the popular Hunter x Hunter, we have Zazan. She is one of the side characters in the show who is a Chimera Ant for her species.

 

As for her overall identity, she is squadron leader of a Chimera Ant group and her own appearance resembles that of a scorpion.

 

All in all, she is quite an attractive being with a lot of powers in her hands. However, that’s just the surface of her character.

 

Because Zazan is a lot more layered than that. She was on the mission to create her own colony with the help of her strength.

 

And with all of that strength in place, she had the potential to achieve her goal and make it to where she wanted to be.

 

 

43. Kaguya Otsutsuki (Naruto)

 

Kaguya Otsutsuki

 

Kaguya Otsutsuki is one of the strongest female characters in all of the anime and there’s no second thought about it.

 

She is one of the side characters in Naruto who happens to gain a ton of traction in the latter half of the series.

 

She is from the infamous Otsutsuki family that goes on to place themselves as some of the strongest beings to ever exist in the narrative of Naruto.

 

And this is the reason why they serve as prime plot makers in Boruto for the current show. Therefore, Kaguya Otsutsuki holds a lot of importance from a narrative as well as a comprehensive standpoint as a female anime villain.

 

 

44. Olive (One Piece)

 

Olive

 

Coming in from the realm of One Piece, we have Olive. She is one of the side characters in the show.

 

And is known for being a fierce pirate in the series. She was first captured by the enemies and was sent to a horrible place that goes by the name Impel Down.

 

However, she managed to escape from that domain and had an impressive bounty over her head. She is known for her 50 million bounties because of her appearance and her personality.

 

She is quite attractive and can melt down anyone and everyone just with her appearance and presence on the battlefield.

 

This is what made her capable of being an anime villain in the first place. And that’s why she is here.

 

 

45. Cornelia Li Britannia (Code Geass)

 

Cornelia Li Britannia

 

She is one of the most renowned anime villains in the medium. And that’s why she deserves a spot on our list.

 

Cornelia Li Britannia is one of the major villains in the anime we know by the name of Code Geass.

 

And that allows her to become more and more recognizable in the long run of the series. She is from the Britannia family and happens to be a Princess for the same.

 

Moreover, as the show progresses, she goes on to become the viceroy of Area 11. Just from her appearance and attitude, it becomes clear that she is a woman of quality and value who shined in this series, brighter than a star.

 

And it was fun seeing her perform some of the most cunning moves in the show.

 

 

46. Catherine Ward (Angels Of Death)

 

Catherine Ward

 

She may look like a simple girl at first. However, that’s just a facade. She is the one who serves as a villain in the series Angels Of Death.

 

And that’s why she is placed here on our list. She is the floor master of B3. And in this anime, this position is enough to give her a lot of traction and attention.

 

As for her presence as the condemner, that’s a profile that gives her even more recognition and power. She is also known to be sadistic by nature and happens to find happiness in taking care of the criminals.

 

However, this care is mostly done in the form of torture and pain. Well, that would explain why she is a noteworthy villain for our list in the first place.

 

 

47. Cassidy (Pokemon)

 

Cassidy

 

This one is a no-brainer. Cassidy is one of the villains in Pokemon who is just like Jessy and James.

 

She also serves Team Rocket and has a lot going for her. Her teammate Butch is a man of quality and value since his chemistry with Cassidy allows her to exponentially enhance her performance in the team.

 

She is a mean and arrogant girl who can be a menace with her tactics and plans. And unlike the regular team rocket, this one is a menace when they are on the screen.

 

While the sheer screen time they have received isn’t a lot, it is still enough to make anyone lose his or her mind.

 

And that’s what makes this girl worthy of this spot on our list. She is just havoc on her own.

 

 

48. Minatsuki Takami (Deadman Wonderland) 

 

Minatsuki Takami (Deadman Wonderland) 

 

Minatsuki Takami, also known as Hummingbird, is Yō Takami’s younger sister and a Deadman who was once confined in G Ward.

 

She had a normal life until she experienced an earthquake while in a greenhouse, where her mother abandoned her and fled with a plant, leaving her behind.

 

Minatsuki, a 17-year-old girl with brown hair in two braided ponytails, initially appears shy and gentle, contrary to her circumstances.

 

She wears a yellow knee-length dress and has a tongue piercing. However, this demeanour serves as a disguise to conceal her true nature and deceive those around her.

 

Despite her reserved and caring personality, there is more to her than meets the eye, leading to an air of mystery and intrigue in her encounters with others, particularly Ganta.

 

 

49. Arbell (One Piece)

 

Arbell

 

Coming in from the realm of One Piece, we have Arbell. She is one of the side characters in her show and belongs to a family called the Accino Family.

 

She is the eldest daughter and has a husband too. His name is Salchow. She is known for being a figure skater in the series.

 

And this passion is shared by both husband and wife in the series. She has the ability to use her legs for various combat purposes and can perform multiple types of kicks that can be lethal during a one-on-one battle.

 

All in all, she was a decent side villain in the story who happens to get a bit of screen time in a massive series like One Piece.

 

And that’s why she deserves a spot on this list.

 

 

50. Yura (InuYasha)

 

Yura

 

Coming from a classic, we have Yura. She is one of the side characters of InuYasha and happened to have a lot going for her.

 

Firstly, she only appeared for a brief amount of time and so, it won’t be a surprise if you don’t recognize her right from the get-go.

 

Secondly, Yura happens to be quite a notable character after her presence since she is in love with physical features like hair.

 

And in the series, it was claimed that she admired InuYasha’s hair more than anything. She is appreciative of her body and her presence on the screen is so evil that we can’t help but look at her as if she is a villain from the heart.

 

However, her design is definitely noteworthy for us.

 

 

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